Camera settings for newborn photo shoot?

What camera settings do you recommend for photographing newborns indoors with natural available window light?
I'm thinking ISO 400-600, F1.4-2.8, 1/125 sec?
Spot metering or dynamic metering and why?
Single focus or continous focus?

* With newborns, I find myself placing the focal point on the eye closest to the camera and then while keeping the shutter pressed half way down recomposing the shot with rule of 1/3rd and pressing shutter completely to take the shot. In order to do this technique must I shoot in single focus area mode? If I were to use this technique in continuous focus area mode would I loose the sharp focus obtained from the eye when I recompose because the camera would then focus on the new focus point I recomposed the camera too?
Thanks for your help and suggestions
**I shoot with a Nikon D300

I wish there was a cookie cutter answer for you. But it depends.
natural light is great use it. Use a reflector light thing to help bounce the light to the other side of the room. DO NOT USE FLASH!
but if it's really sunny and the sun blares through the window that will be a different setting on an overcast day with no sun coming through the window.

There's no wrong or right answer either. Keep playing around in doors with your camera settings and see what gives you the best image.

I just did this in a hospital room with my camera. I did jack up my ISO and we had not much lighting to use. We did crank up all the lights in the room and i can't remember any setting but my iso. I hate putting my iso so high. But I had to for the effect i was going for. The messed up part is i gave my husband the camera and he dn't know how to shoot. And i'm glad the iso was so high as he didn't blur the images.
i was set on spot metering as well.

We can't tell you what settings -we aren't there! It depends entirely on the ambient light level.

You use the light meter that your camera has to set the exposure. Ideally you keep the ISO as low as possible and the shutter speed enough to prevent motion blur.

I always spot meter and use single point focus.

Honestly, you need to know this stuff BEFORE you start hiring yourself out for photoshoots - this is basic stuff.

And as for 'madluv's' exhortation not to use flash - no good reason why not. As long as you use it off camera and know how to modify it, it can be a powerful additional tool and essential for a portrait photographer. Those who don't like flash are those who just don't know how to use it.

I sure hope you are not charging money, because you are clueless.

If you use continuous auto focus, your camera will re focus when you move to change the framing (duh).

As another answer has already said, we can't tell you what exposure settings to use since we have no idea of the exact lighting. Use you camera's internal light meter (duh).

Finally, using apertures of 1.4-2.8 will probably give you a depth of field that is too narrow (but we would need to know the focal length of the lens, which you probably do not understand either).

Here is a crazy idea, get an object about the size of a newborn (a bag of flour or sugar will work) and take some practice shots in lighting you expect to have and see what happens. Or are you too much of a professional to practice?